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Antimicrobial activity of sulfobetaine type surfactants





Key words: 

sulfobetaine, surfactants, antimicrobial activity.


Microbiological pollution, as well as the maintenance of proper hygiene and cleanliness are topics that cover a wide range of literature. The need of obtaining new compound with high antimicrobial activity is closely related to the fact that increased resistance of pathogenic bacteria and fungi to different antibiotics became worldwide problem. One of the solutions can be a synthesis of new biocides for e.g. surfactants. Antibacterial and antifungal activities of surfactants are one of the most desirable features of these compounds. The best known surfactants that exhibit such activity are quaternary ammonium compounds. It is believed that this group of surface active agents shows the highest antagonistic effect against Gramnegative, Gram-positive bacteria, fungi and yeast. However, literature data shows that also sulfobetaine type surfactants can be very good antiseptic substances.  Presented data showed that sulfobetaines exhibit high antibacterial activity. Comparison of sulfobetianes activity with activity of commercially used surfactants indicated that in many cases sulfobetaines are better antiseptic agents, however it depends on tested bacteria. Observed activity of sulfobetaines against Gram-positive bacteria is higher than Gramnegative ones. Furthermore this activity depends not only on the length of hydrophobic alkyl chain, but also from the structure of hydrophilic head. The same conclusions can be stated when concerning the activity against Candida Albicans fungi.
 dr hab. inż. Daria WIECZOREK dr Dobrawa KWAŚNIEWSKA

Poznan University of Economics and Business, Faculty of Commodity Science, 

Department of Technology and Instrumental Analysis, 

Aleja Niepodległości 10, 61-875 Poznan,

Poland e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

dr Ying-Lien CHEN dr Tang-Long SHEN

National Taiwan University,

Department of Plant Pathology and Microbiology No.1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan





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